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Hamartia Hamartiology Hamartoma Hamartoses Hamartomatosis Hamartomatoses
~ HAMARTIA id+ | FLAW FLAWED ERROR DEFECTIVE MALFORMED SIN | ~ HAMARTIOLOGY id+ | THEOLOGY focused on SIN | ~ HAMARTOMA id+ | OVERGROWTH OF MATURE CELLS NORMAL TO THE SITE | id+ | MALFORMED TISSUES or TUMORS | id+ | FOCAL TISSUE MALFORMATION | ~ HAMARTOSES pl of HAMARTOMA ~ HAMARTOMATOSIS or ~ HAMARTOMATOSES id+ | MULTIPLE HAMARTOMAS due to a GENETIC MUTATION | id+ | TRAGEDY | etym> note duality FLAW ERROR MALFORMATION and TRAGEDY gr HAMARTEIN = TO ERR HAMARTIA FLAW TRAGEDY see SOPHOCLES below lit+ SOPHOCLES [#] in OEDIPUS REX illustrates HAMARTIA with "THE TYRANT IS A CHILD OF PRIDE WHO DRINKS FROM HIS GREAT SICKENING CUP RECKLESSNESS AND VANITY UNTIL FROM HIS HIGH CREST HEADLONG HE PLUMMETS TO THE DUST OF HOPE" and Alexander POPE [#] in "An Assay on Man" elaborates "IT IS ONLY BY KNOWING THYSELF THAT THOU WILT RID THYSELF OF THY HAMARTIA" med> HAMARTOMA mostly implies altered PRENATAL DEVELOPMENT of TISSUES in terms of "COMBINATION" "ORGANIZATION" and EXCESS OF GROWTH OF MATURE CELLS NORMAL TO THE SITE note NONETHELESS HIGH CANCER RISK MUST BE SUSPECTED most HAMARTOMAS MAY BE POST NATAL as per CARCINOGENIC CAUSES eg RADIATION WHICH DISRUPT TISSUES note alt definition HISTOLOGIC ORGANIZATION causing altered CELL GROWTH leading to the formation of "TUMOR" or NODULES or CYSTS or NEOPLASIA note MOST TUMORS OF THE LUNGS ARE HAMARTOMAS note CARDIAC HAMARTOMAS ARE OFTEN RHABDOMYOMAS ASSOCIATED WITH TUBEROUS SCLEROSIS note COWDEN SYNDROME IMPLIES MULTIPLE HAMARTOMAS INCLUDING OF SKIN in OVER 60% OF PATIENTS plus THYROID EYES etc note ANY INSTANCE OF MULTIPLE HAMARTOMAS SHOULD EVOKE SUSPICION OF A HIGH CANCER RISK SYNDROME sug> POLYP PAPYLOMA ADENOMA FIBROMA note "CYSTS" most often are HAMARTOMATOUS see> TERATOMA TERATOLOGY med> GENETIC HAMARTOSES is a group of disorders included are NEUROFIBROMATOSES characterized by the development and growth of MULTIPLE hamartomas eg NEUROFIBROMAS LIPOMA GLIOMA HAMARTOMAS can undergo MALIGNANT or CANCEROUS or DEGENERATION thus give rise to SARCOMA CARCINOMA and LEUKEMIA cont> TRAGEDY |