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MONA LISA
"Mona Lisa or Monna or La Jaconda or Lisa Gherardini" (see related A), 1503 - 1517 Leonardo da Vinci (1452-1519) Louvre Museum, Paris, France
This is the "opus magnus" of Leonardo - it traveled with him since its start through the rest of his life. Obviously, he was aware of the unique nature of this portrait.
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