(details from "La Primavera"), 1480 Alessandro Filipepi (known as Botticelli) (1445 - 1510) Uffizi Gallery, Florence, Tuscany, Italy

Nobody knows what Botticelli had in mind - perhaps Zephyr was cold, and the rigor caused his cyanosis, as well as frigidity in the nymph Chloris he is embracing - his cheeks show he is blowing his spirit (breath) into the maiden (his buccinator (peri-oral facial muscles) appears vigorous) - perhaps Chloris will metamorphose into Flora, shown here clad in flowers (Botticelli enriched this painting with hundred of species of flowers, magnify the view and see how many you detect). 

Among mortals, some have a face or rather a facies with puckered lips - they can not "blow" - their buccinator muscles are paralyzed - they can not whistle (Whistling Face Syndrome) and, concurrently, have contracted or spasticity of other muscles, in particular those of the hands and feet. Some also had a cardiomyopathy (see our Clinical Eye Openers website regarding this autosomal dominant myopathy syndrome generally called Freeman Sheldon Syndrome).