"Ferdinando I" (see related A | B | C | D | E), 1587 Cristofano dell'Altissimo (c. 1525-1605) Uffizi Gallery, Florence, Tuscany, Italy

Member of the Habsburg (Hapsburg) clan and inheritor of an autosomal dominant mutation that causes overgrowth of the mandible, lip, and, perhaps, the nasal dorsum. Medically, the question is from whom did he inherit the genetic mutation, and what were the functional consequences - an interesting research project for clinical investigators and medical historians.