"Maria Anna or Mariana de Austria, Reina y consorte de Felipe IV " (see details) (see related A) Diego Rodriguez de Silva y Velazquez (1599-1660) Kunsthistorisches Museum, Vienna, Austria

The H+ facies of Mariana is obvious. Her reproductive history is pathetic: her first child was a daughter that died at 21 years of age; the second and third daughters were stillborn; next, two sons, Felipe Prospero and Fernando Tomas, died at the age of 4 and 1 respectively; and, finally, was born Carlos II, who manifested H+ plus many very serious developmental deficits (see the page dedicated to him). Note that the father or Carlos II and consort of Mariana also manifested H+. It is entirely possible that Carlos II and many of his deceased siblings were "double hit" victims, a vernacular mode to denote that they inherit one H+ mutated gene from Felipe and another H+ mutated gene from their mother Mariana. PLEASE NOTE that there are companion videos on this point - "Game of thrones - Bastards - Emperors - Genes". Please also see companion images which contain many other comments.